Arrowhead Achieves Clinical Validation for New Drug Platform

Arrowhead Pharmaceuticals (NASDAQ:ARWR) on Tuesday shared interim topline clinical data from a Phase 1/2a trial. The trial is evaluating ARO-DIMER-PA, the company’s first investigational RNA interference (RNAi) therapeutic dimer for atherosclerotic cardiovascular disease (ASCVD) due to mixed hyperlipidemia. Hyperlipidemia is defined by an excess of fats, or lipids—such as cholesterol and triglycerides—in the blood. Read Also: Arrowhead Drug Shows Strong Efficacy In Cutting Blood Fat Interim ARO-DIMER-PA Data Arrowhead Pharmaceuticals announced interim topline clinical data for ARO-DIMER-PA, saying the program achieved deep and durable silencing of two genes with a single RNAi molecule. The company reported mean maximal single-dose reductions of 72% in serum PCSK9 and 88% in APOC3. Silencing of both the PCSK9 and APOC3 genes led to favorable changes in lipids and lipoproteins, including LDL-C reduction of 54%, triglyceride reduction of 73%, non-high-density lipoprotein cholesterol reduction of 61%, and Apolipoprotein B reduction of 50%. “ARO-DIMER-PA also fits well strategically with Arrowhead’s growing focus on cardiometabolic diseases. It is complemented by our existing portfolio, which includes our first commercial product REDEMPLO (plozasiran)… and investigational zodasiran, which is currently being studied in the global Phase 3 YOSEMITE clinical trial in patients with homozygous familial hypercholesterolemia,” said Chris Anzalone, President and CEO at Arrowhead. ARWR Analyst Consensus & Recent Actions The stock carries a Buy rating with an average price forecast of $102.09. Recent analyst moves include: Citigroup: Initiated with Buy (Price Forecast $108.00) (September 8) HC Wainwright & Co.: Buy (Maintains Price Forecast at $120.00) (September 1) Chardan Capital: Buy (Maintains Price Forecast at $115.00) (August 31) How Arrowhead (ARWR) Ranks On Momentum And Signals Below is the Benzinga Edge scorecard for Arrowhead Research, highlighting its strengths and weaknesses compared to the broader market: Momentum: Bullish (Score: 94.87) — The stock is screening as a strong momentum name versus the broader market, despite the current pullback. The Verdict: Arrowhead Research’s Benzinga Edge signal reveals a momentum-driven story, with the scorecard heavily concentrated in Momentum. For traders, that often means the next clean signal comes from whether price can reclaim the 200-day area and build a higher low off the oversold RSI backdrop. ARWR Price Action: Arrowhead Pharma shares were up 0.68% at $71.15 during premarket trading on Wednesday, according to Benzinga Pro data. Read Also: Elon Musk Predicts Solar Will Crush All Other Energy Sources to Below 0.1% Amid Texas Boom: ‘So Obviously the Future’ Photo by T. Schneider via Shutterstock